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OCR: arily affect The fibric acid derivatives (fibrates) pri is reduced VLDL metabolism, whereby VLDL inpu se and removal is enhanced. Their major therefore is for the treatment of o increase hypertriglyceridaemia, in which they a HDL levels. is also a Probucol reduces LDL and HDL levels. I in to powerful anti-oxidant and has been sho ent of inhibit lipoprotein oxidation and the ex Its use as atherosclerosis in experimental animal nature. an anti-oxidant in man is, however, pre